Avtor/Urednik		Šmuc, Tina; Hevir, Neli; Ribič-Pucelj, Martina; Husen, Bettina; Thole, Hubert; Lanišnik-Rižner, Tea
Naslov		Disturbed estrogen and progesterone action in ovarian endometriosis
Tip		članek
Vir		Mol Cell Endocrinol
Vol. in št.		Letnik 301
Leto izdaje		2009
Obseg		str. 59-64
Jezik		eng
Abstrakt		Endometriosis is a very common disease in pre-menopausal women, where defective metabolism of steroid hormones plays an important role in its development and promotion. In the present study,we have examined the expression of 11 estrogen and progesterone metabolizing enzymes and their corresponding receptors in samples of ovarian endometriomas and control endometrium. Expression analysis revealed significant up-regulation of enzymes involved in estradiol formation (aromatase, sulfatase and all reductive 17alpha-hydroxysteroid dehydrogenases) and in progesterone inactivation (AKR1C1 and AKR1C3). Among the estrogen and progesterone receptors, ERalpha was down-regulated, ER was up-regulated, and there was no significant difference in expression of progesterone receptors A and B (PRAB). Our data indicate that several enzymes of estrogen and progesterone metabolism are aberrantly expressed in endometriosis, which can lead to increased local levels of mitogenic estradiol and decreased levels of protective progesterone. Changes in estrogen receptor expression suggest that estradiol may also act via non-estrogen receptor-mediated pathways, while expression of progesterone receptors still needs further investigation.
Deskriptorji		ENDOMETRIOSIS OVARIAN DISEASES 17-HYDROXYSTEROID DEHYDROGENASES RECEPTORS, ESTROGEN RECEPTORS, PROGESTERONE PROGESTERONE PROMOTER REGIONS (GENETICS) ALDEHYDE REDUCTASE IMMUNOHISTOCHEMISTRY ADULT