Avtor/Urednik		Clausen, Anders Ranegaard; Girandon, Lenart; Knecht, Wolfgang; Survery, Sabeen; Andreasson, Erik; Munch-Petersen, BBirgitte; Piškur, Jure
Naslov		A multisubstrate deoxyribonucleoside kinase from plants
Tip		članek
Vir		Nucleic Acids Symp Ser
Vol. in št.		, št. 52
Leto izdaje		2008
Obseg		str. 489-90
Jezik		eng
Abstrakt		Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.