Avtor/Urednik | Lundgren, Stina; Andersen, Birgit; Piškur, Jure; Dobritzsch, Doreen | |
Naslov | Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster | |
Tip | članek | |
Vir | Acta Cryst Sec F | |
Vol. in št. | Letnik 63, št. Pt 10 | |
Leto izdaje | 2007 | |
Obseg | str. 874-7 | |
Jezik | eng | |
Abstrakt | Beta-alanine synthase catalyzes the last step in the reductive degradation pathway for uracil and thymine, which represents the main clearance route for the widely used anticancer drug 5-fluorouracil. Crystals of the recombinant enzyme from Drosophila melanogaster, which is closely related to the human enzyme, were obtained by the hanging-drop vapour-diffusion method. They diffracted to 3.3 A at a synchrotron-radiation source, belong to space group C2 (unit-cell parameters a = 278.9, b = 95.0, c = 199.3 A, beta = 125.8 degrees) and contain 8-10 molecules per asymmetric unit. | |
Deskriptorji | AMIDOHYDROLASES ANIMALS CRYSTALLIZATION CRYSTALLOGRAPHY, X-RAY DROSOPHILA MELANOGASTER |