Avtor/Urednik		Sandrini, Michael P; Piškur, Jure
Naslov		Deoxyribonucleoside kinases: two enzyme families catalyze the same reaction
Tip		članek
Vir		TRENDS BIOCHEM SCI
Vol. in št.		Letnik 30, št. 5
Leto izdaje		2005
Obseg		str. 225-8
Jezik		eng
Abstrakt		Mammals have four deoxyribonucleoside kinases, the cytoplasmic (TK1) and mitochondrial (TK2) thymidine kinases, and the deoxycytidine (dCK) and deoxyguanosine (dGK) kinases, which salvage the precursors for nucleic acids synthesis. In addition to the native deoxyribonucleoside substrates, the kinases can phosphorylate and thereby activate a variety of anti-cancer and antiviral prodrugs. Recently, the crystal structure of human TK1 has been solved and has revealed that enzymes with fundamentally different origins and folds catalyze similar, crucial cellular reactions.
Deskriptorji		ANIMALS MODELS, MOLECULAR MULTIGENE FAMILY NUCLEIC ACID PRECURSORS PROTEIN STRUCTURE, TERTIARY SUBSTRATE SPECIFICITY