Avtor/Urednik		Piškur, Jure; Sandrini, Michael P; Knecht, Wolfgang; Munch-Petersen, Birgitte
Naslov		Animal deoxyribonucleoside kinases: 'forward' and 'retrograde' evolution of their substrate specificity
Tip		članek
Vir		FEBS Lett
Vol. in št.		Letnik 560, št. 1-3
Leto izdaje		2004
Obseg		str. 3-6
Jezik		eng
Abstrakt		Deoxyribonucleoside kinases, which catalyse the phosphorylation of deoxyribonucleosides, are present in several copies in most multicellular organisms and therefore represent an excellent model to study gene duplication and specialisation of the duplicated copies through partitioning of substrate specificity. Recent studies suggest that in the animal lineage one of the progenitor kinases, the so-called dCK/dGK/TK2-like gene, was duplicated prior to separation of the insect and mammalian lineages. Thereafter, insects lost all but one kinase, dNK (EC 2.7.1.145), which subsequently, through remodelling of a limited number of amino acid residues, gained a broad substrate specificity.
Deskriptorji		EVOLUTION, MOLECULAR AMINO ACID SEQUENCE ANIMALS CONSERVED SEQUENCE DNA MOLECULAR SEQUENCE DATA NUCLEIC ACID PRECURSORS PHOSPHORYLATION PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR) PHYLOGENY POINT MUTATION SEQUENCE HOMOLOGY, AMINO ACID STRUCTURE-ACTIVITY RELATIONSHIP SUBSTRATE SPECIFICITY