Avtor/Urednik		Ovčak, Z
Naslov		Pomen intermediarnih filamentov in lektinskih receptorjev za določevanje histogeneze ledvičnega adenokarcinoma
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		1992
Obseg		str. 85
Jezik		slo
Abstrakt		Fifty-four cases of renal cell carcinoma, one oncocytoma and two adenomas of the kidney were studied. We classified these tumors according to Thoenes classification (1986) considering the mode of tumor growth and cell types. Immunohistochemically we demonstrated four intermediate filaments in tumor cells: three cytokeratins (CK 7,8,18) and vimentin. The cytokeratins were found in 43 cases of studied tumors. In eight tumors the co-expression of cytokeratins and vimentin was detected.Six tumors expressed only vimentin. Vimentin was detected predominantly in less differentiated and spindle-cell tumors. It was, found in clear, chromophilic and spindle-cells but never in chromophobe cells and oncocytes. In 69 per cent of cases we found the expression of CK 18 alone or together with other two cytokeratins or vimentin. CK 7 was present in 25 and CK 8 only in 7 cases. In less differentiated tumors, the immunoreactivity of cytokeratins was less emphasized, whereas that of vimentin was more friquent. We also studied the lectin-binding sites on tumor cells. Three lectins were examined: MPA, a marker for distal part of the nephron and RCA II and PHA-E which are characteristic for proximal tubules. In 23 cases we demonstrated simultaneous binding of lectins characteristic for proximal and distal parts of the nephron. These results were irrespective of tumor cell-types or the grade of differentiation. 11 cases were completely devoid of lectin binding sites. The results of immunohistochemical studies of IF suggest that chromophobe cell carcinoma and renal oncocytoma represent a separate entities of kidney tumors, probably arising from the collecting tubules. The occasional expression of vimentin in the renal cell carcinoma correspondes with the mesodermal origin of the kidney, showing also the regressive antigenic phenotype of less differentiated tumors.(trunc.)
Deskriptorji		KIDNEY KIDNEY NEOPLASMS INTERMEDIATE FILAMENTS ADENOCARCINOMA KERATIN LECTINS