Avtor/Urednik		Vitali, C; Bencivelli, W; Isenberg, DA; Smolen, JS; Snaith, ML; Sciuto, M; Bombardieri, S; Rozman, B
Naslov		Disease activity in systemic lupus erythematosus: report of the Consensus study group of the European workshop for rheumatology research. III. Development of a computerised clinical chart and its application to the comparison of different indices of disease activity
Tip		članek
Vir		Clin Exp Rheumatol
Vol. in št.		Letnik 10, št. 5
Leto izdaje		1992
Obseg		str. 549-54
Jezik		eng
Abstrakt		In the first phase of this study, a data-base containing clinical and laboratory findings of 704 patients with systemic lupus erythematosus (SLE), originating from 29 centres and 14 countries, was used to assess the validity of 4 common indices of disease activity, SLAM, BILAG < SLEDAI and SIS. The physician;s judgement of activity was assumed activity indices; this computation appeared to correspond with manual computation appeared to correspond with manual computations in a sample of 60 approapriately selected cases. All 4 indices were closely correlated with each other (r in the range of 0.716 to 0.872), and with the physician's score (r in the range of 0.620 to 0.719). In the second phase of the study the activity index developed in part I (ECLAM) was prospectively validated, and its performance compared to that of the other scales, both as a single state index and as a transition index (i.e., its ability to assess disease activity a single point in time and to detect cariations in consecutive readings). A computer-assisted clinical chart was prepared for this purpose. This chart allowed us to calculate automatically all the indices. Two consecutive observation times (time 0, and time I three months later) were included in the study protocol. Data on 75 patients from 19 centres were collected, and each patient was observed twice. All the computed indices were closely correlated, both at time 0 (r ranging from 0.725 to 0.884), and at time I (r ranging from 0.607 to 0.833). The correlation coefficients with physician's score were slightly lower, specifically for the second observation. However, ECLAM and SLEDAI at the first observation, and BILAG and ECLAM at the second, were the indices with the highest predictive value with respect to the physician's judgement. The present study provides not only a validation of the different indices of disease activity, but also a uniform data base for SLE, including a computerised clinical chart.(trunc.)
Deskriptorji		LUPUS ERYTHEMATOSUS, SYSTEMIC SEVERITY OF ILLNESS INDEX DIAGNOSIS, COMPUTER-ASSISTED EUROPE MULTICENTER STUDIES SOFTWARE