Avtor/Urednik		Sketelj, J; Brzin, M
Naslov		Intrinsic regulation and neural modulation of acetylcholinesterase in skeletal muscles
Tip		članek
Vir		In: Massoulie J et al, eds. Cholinesterases: structure, function, mechanism, genetic and cell biology. Proceedings of the 3rd international meeting on cholinesterases, La Grande-Motte, France; 1990 May 12-16; Washington: American chemical society,
Leto izdaje		1991
Obseg		str. 66-70
Jezik		eng
Abstrakt		Development of motor endplates after early postnatal denervation of rat soleus muscles and the changes of AChE molecular forms pattern in slow and fast muscles after experimental disturbances of neural input were studied in order to elucidate the importance of neural influences vs. intrinsic muscle mechanisms in nezve-muscle interactions. The postsynaptic-like sarcolemma differentiation including both AChE and acetylcholine receptor accumulation and growth of sarcolemmal folds continued after early postnatal denervation and even expanded to much greater length than that of normal motor endplates at the same age. Exaggerated expansion of the sarcolemmal postsynaptic-like differentiation after denervation may be due to release from a neural inhibitory influence on accumulation of synaptic components in immediate vicinity of the motor endplates. Procedures which disrupted normal stimulation pattern of rat muscles (tenotomy, denervation, reinnervation of regenerating muscles) did not change the typical features of the patterns or distribution of AChE molecular forms in slow and fast muscles. The results support the hypothesis that intrinsic differences in AChE regulation largely determine the specific AChE patterns in slow and fast rat muscles.
Deskriptorji		MOTOR ENDPLATE CHOLINE ACETYLTRANSFERASE RATS NEURAL INHIBITION MUSCLE DENERVATION