Avtor/Urednik		Fister, Petja; Gaberšček, Simona; Zaletel, Katja; Krhin, Blaž; Geršak, Ksenija; Hojker, Sergej
Naslov		Thyroid volume changes during pregnancy and after delivery in an iodine-sufficient Republic of Slovenia
Tip		članek
Vir		Eur J Obstet, Gynecol, Reprod Biol
Vol. in št.		Letnik 145, št. 1
Leto izdaje		2009
Obseg		str. 45-8
Jezik		eng
Abstrakt		Objective: Literature data concerning thyroid enlargement during pregnancy are not conclusive. Our aim was to systematically follow the thyroid volume changes during pregnancy and after delivery in an iodine-sufficient area. Sudy design: Prospective study of healthy pregnant women living in an iodine-sufficient area. We followed 118 pregnant women with the mean age 30.9+/-4.1 years in the first trimester (mean 11.2+/-2.5 weeks of pregnancy), in the third trimester (mean 31.6+/-1.7 weeks of pregnancy), and 4 months after delivery (mean 15.9+/-3.9 weeks). Additionally, 71 women were also evaluated 14 months after delivery (mean 13.3+/-1.1 months). All women were negative for thyroid autoantibodies. We measured urinary iodine concentration (UIC), thyroid volume, serum TSH, and body mass index (BMI). After delivery, in a subgroup of women we also estimated the colour flow Doppler sonography (CFDS) patterns 0, I, II and III, where thyroid vascularity increased from pattern 0 to III, and the peak systolic velocity (PSV) using a 7.5 mHz linear transducer. Results: Median UIC in the third trimester (176 microg/g creatinine) was significantly higher than 4 and 14 months after delivery (P=0.030, P<0.001, respectively). Thyroid volume in the third trimester (11.3+/-3.1 mL) was significantly greater (P<0.001) than in the first trimester (8.7+/-2.5 mL), 4 months after delivery (8.6+/-2.5) and 14 months after delivery (7.8+/-2.4 mL). TSH concentration was significantly higher in the third trimester than in the first trimester and 4 months after delivery (P=0.007, P=0.006, respectively). As expected, BMI was the highest in the third trimester. CFDS pattern I was more frequent 4 months after delivery than 14 months after delivery (P<0.001). Similarly, PSV was significantly higher 4 months after delivery than 14 months after delivery (P<0.001). (Abstract truncat at 2000 characters)
Deskriptorji		THYROID GLAND THYROTROPIN IODINE BODY MASS INDEX PREGNANCY PUERPERIUM PROSPECTIVE STUDIES