Avtor/Urednik		Ledinek-Horvat, A; Jazbec-Šega, S; Drinovec, I; Rot, U
Naslov		Pulmonary arterial hypertension associated with interferon beta treatment for mulktiple sklerosis: a case report
Tip		članek
Vir		Multiple Sclerosis
Vol. in št.		Letnik 15, št. 7
Leto izdaje		2009
Obseg		str. 885-6
Jezik		eng
Abstrakt		A 23-year-old woman with multiple sclerosis developed respiratory symptoms 3 years after introduction of interferon beta-1b. The diagnosis of pulmonary arterial hypertension (PAH) was established. The patient partially responded to sildenafil and bosetan treatment. This is the first report of PAH, associated with interferon beta therapy. As shown in experimental models, interferon treatment can induce PAH by stimulation of thromboxane cascade and secretion of various inflammatory mediators.