Avtor/Urednik		Glaser, Marjana; Goropevšek, Aleš
Naslov		Pomen pretočne citometrije pri ugotavljanju redkih oblik limfomov
Prevedeni naslov		The importance of flow cytometry in diagnosis of rare lymphomas
Tip		članek
Vir		In: Križman I, editor. Zbornik predavanj 3. kongres Združenja internistov Slovenije; 2009 sep 25-26; Ljubljana. Ljubljana: Združenje internistov SZD,
Leto izdaje		2009
Obseg		str. 133-8
Jezik		slo
Abstrakt		Hepatosplenic lymphoma is a rare form of peripheral T cell lymphoma, which affects mostly middle aged male population. The cause of the disease is unknown. There are some case reports of the disease appearance after solid organ transplantation, but not after delivery. There are some case reports of the disease appearance after solid organ transplantation, but not after delivery. Case report. A 19 years old woman was admitted to our department because of clearing up hepatosplenomegaly, pancytopenia and appearance of hematomas. 3 months before the admitance she gave birth to a daughter. Using flow cytometry we suspected, that she suffered of gamma/ delta T cell hepatosplenic lymphoma. We confirmed our suspition some days later with bone marrow and liver biopsy. Discussion. Flow cytometry can be themethod of selection in case of unexplained pancytopenia and hepatosplenomegaly, especially in case of a suspected rare blood disease ( in our case T cell hepatosplenic lymphoma). The method is fast, but needs an investigator with enough experience to identify clonal changes of T lymphocytes. As the patient must be treated as soon as possible, it is necessary a good cooperation between clinic (-s), laboratory diagnostics for flow cytometry and the pathologist.
Izvleček		Hepatosplenični limfom je redka oblika perifernega T celičnega limfoma, ki prizadene predvsem moške srednjih let. Vzrok je neznan. Opisani so primeri pojava bolezni po transplantaciji solidnih organov, ne pa po porodu. Prikaz bolnice. 19 letna bolnica je bila sprejeta zaradi razjasnitve hepatosplenomegalije, pancitopenije in pojava hematomov. 3 mesece prej je rodila hčerko. 5 pretočno citometrijo smo posumili, da ima T celični gama/ delta HSTL, kar smo kasneje potrdili z biopsijo kosti in jeter. Diskusija. Pretočna citometrija je lahko metoda izbora pri bolnikih z nepojasnjeno pancitopenijo in hepatosplenomegalijo, predvsem v primerih, ko sumimo na redko krvno obolenje (v našem primeru periferni hepatosplenični T celični limfom). Metoda je hitra, vendar pa mora imeti preiskovalec dovolj izkušenj za prepoznavanje klonalnih sprememb T limfocitov. Ker moramo pričeti bolnika čim hitreje zdraviti, je nujno potrebno dobro sodelovanje med kliniko ( -ami), diagnostiko v laboratoriju za pretočno citometrijo in patologom.
Deskriptorji		LYMPHOMA T-LYMPHOCYTES FLOW CYTOMETRY