Avtor/Urednik		Hajdinjak, Tine; Modrič, Evgenija
Naslov		Primerajava občutljivosti urinskih testov UBC ELISA in ETA Trak pri odkrivanju ponovitev tumorja mehurja
Prevedeni naslov		Comparsion of the UBC ELISA test and the BTA Trak test for the detection of bladder tumor recurrence
Tip		članek
Vir		Acta medico-biotechnica : AMB
Vol. in št.		Letnik 2, št. 1
Leto izdaje		2009
Obseg		str. 55-60
Jezik		eng
Abstrakt		Purpose: To compare the sensitivity of the stablished BTA Trak[TM] test with the newer UBC ELISA[TM] test for the detection of bladder tumor recurrence. Methods: Urine samples from 63 patients were collected prior to cystoscopy. In cases of positive cystoscopy findings, patients were scheduled for TUR and the histologic findings were correlated with the urine test results. Results: There are a statistically significant increase in median UBC value with increasing tumor grade. Median UBC values (microg/L) for tumor stages were: 22.1, 47.5, 95.7 and >150 for pTa, pT1, pT2/3 and CIS, respectively. The overall sensitivity of the UBC and BTA was 62 % and 90 % (p=0.0049). Comparing different tumor stages, the sensitivity for the UBC vs. BTA was 52 % vs. 86 % (p=0.022) in pTa, 56 % vs. 100 % (p=0.039) in pT1, 83 % for both tests in pT2/3 and 100 % for both in CIS. In low grade tumors, the sensitivity of the UBC vs. BTA was 47 % vs. 84 % (p=0.022); in high grade tumors it was 75 % vs. 95 % (NS p=0.085). The combination of both tests did not increase sensitivity over BTA alone. Overall specificity for the UBC was 71 % and for the BTA 50 % (NS). Overall test accuracy for the UBC 65 % was and for the BTA 75 % (NS). Conclusion: The UBC ELISA[TM] in its present form did not have better sensitivity than the BTA Trak[TM] test because of its lower validity in low grade/stage tumors.
Izvleček		Namen: Primerjati natančnost pri odkrivanju ponovitev tumorja mehurja med uveljavljenim testom BTA Trak[TM] in novejšim testom UBC ELISA[TM]. Metode: Testiranih je bilo 63 vzorcev urina, ki so bili odvzeti pred kontrolno cistoskopijo. V primeru pozitivnega izvida cistoskopije je bila opravljena operativna odstranitev tumorja. Rezultat izvida vzorca urina je bil ovrednoten glede na rezultat cistoskopije in histološke preiskave. Rezultati: Mediana vrednost UBC je bila pri slabše diferenciranih tumorjih statistično pomembno višja. Mediane vrednosti UBC (mikrog/L) glede na stadij tumorja so bile: 22.1, 47.5, 95.7 in >150 za pTa, pT1, pT2/3 in CIS. Občutljivost testov UBC in BTA za vse vzorce je znašala 62 % in 90 % (p=0.0049). Glede na stadije je primerjava občutljivosti med BTA in UBC pri pTa pokazala 52 % proti 86 % (p=0.022), pri pT1 56 % proti 100 % (p=0.029), 83 % za oba testa pri pT2/3 in 100 % pri CIS. Za tumorje nizkega gradusa je bila občutljivost UBC 47 %, BTA 84 % (p=0.022), za tumorje visokega gradusa pa 75 % in 95 % (p=0.085). Kombinacija obeh testov v primerjavi z uporabo samo testa BTA občutljivosti niizboljšala. Specifičnost je na celotnem vzorcu za UBC znašala 71 % in za BTA 50 % (p>0.1). Izračunana natančnost testa UBC je za preučevani vzorec znašala 65 %, natančnost testa BTA pa 75 %. Zaključek: Test UBC ELISA[TM] ni pokazal boljše občutljivosti v primerjavi s testom BTA Trak[TM], in sicer predvsem zaradi slabših rezultatov pri bolje diferenciranih tumorjih in tumorjih nižjega stadija.
Deskriptorji		TUMOR MARKERS, BIOLOGICAL SENSITIVITY AND SPECIFICITY