Avtor/Urednik		Debeljak, A; Križnar, K; Bizjak, M
Naslov		Kompleks serinske elastaze z alfa ena proteaznim inhibitorjem v pljučih kadilcev
Prevedeni naslov		Serine elastase - alpha 1 protease inhibitor complex in the lung of smokers
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 62, št. 4
Leto izdaje		1993
Obseg		str. 149-52
Jezik		slo
Abstrakt		Background. The authors wanted to find out if serine elastase (PMN elastase) - alpha 1 protease inhibitor (alpha 1 Pi) complex in bronchoalveolar lavage (BAL) fluid is higher both in smokers and in patients with chronic obstructive pulmonary disease (COPD). Methods. By prospective study in randomly selected 15 nonsmokers, 20 smokers and 16 smokers with COPD during bronchoscopy BAL was performed. The examined persons were included into the study if because of inflammatory or malignant lung diseases bronchoscopy was indicated. In BAL fluid the concentration of PMN elastase - alpha 1 Pi complex was determined using the heterogenous enzyme immunoassay 12589 Elastase Merck. Results. The relative concentration of PMN elastase - alpha 1 Pi complex in nonsmokers was 1.97 +- 2.01 micro g/mg albumin, in smokers 1.99 +- 2.12 micro g/mg albumin and 2.16 +- 2.10 micro g/mg albumin in patients with COPD. The differences were unsignificant. Conclusions. Cigarette smoking and COPD do not change the PMN elastase - alpha 1 Pi complex concentration in the lung. We think that in nonsmokers all alpha 1 Pi is already combined with PMN elastase. That is the reason why in smokers and patients with COPD the PMN elastase - alpha 1 Pi complex concentration in BAL fluid can not be elevated.
Deskriptorji		SMOKING LUNG DISEASES, OBSTRUCTIVE ALPHA 1-ANTITRYPSIN BRONCHOALVEOLAR LAVAGE FLUID