Avtor/Urednik		Trontelj, JV; Janko, M
Naslov		The pathophysiological mechanism of fasciculations in normal people
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 62, št. 10
Leto izdaje		1993
Obseg		str. 435-9
Jezik		eng
Abstrakt		Single fiber EMG (SFEMG) was used to record fasciculation potentials in normal persons in an attempt at elucidating the underlying mechanisms. The recordings often consisted of single biphasic spikes of constant shape. Some of these however intermittently disintegrated into two spike components or became reduced in amplitude with a notch appearing in the previously smooth biphasic shape. Alternatively, the spike amplitude and duration became, in some discharges, suddenly reduced. These observations suggested that the original wave form actually represented two or several single fiber components fused into what satisfied the criteria of a single fiber action potential, without visible "internal jitter" or jiggle. Less frequently, multiple spike discharges were recorded, with low or moderate jitter with or without intermittent blocking of the individual single fiber components. These findings are believed to suggest ephaptic transmission ofactivity between muscle fibers participating in this type of fasciculations. Evidence is presented of other instances suggestive of ephaptic transmission between individual muscle fibers in human muscle, both denervated and normal, supporting the proposed explanation.
Deskriptorji		FASCICULATION MUSCLES ELECTROMYOGRAPHY ELECTRIC STIMULATION ACTION POTENTIALS SYNAPTIC TRANSMISSION