| Avtor/Urednik | Šuškovič, S | |
| Naslov | Lastnosti bronhijalne prevzdražljivosti pri astmi | |
| Prevedeni naslov | Features of bronchial hyperresponsiveness in asthma | |
| Tip | članek | |
| Vir | Zdrav Vestn | |
| Vol. in št. | Letnik 62, št. 10 | |
| Leto izdaje | 1993 | |
| Obseg | str. 451-5 | |
| Jezik | slo | |
| Abstrakt | Background. Nonspecific bronchial hyperresponsiveness (NBHR) determines many clinical features of asthma. NBHR is disclosed by bronchial provocation tests (BPT) by many agonist and analysed by parameters of BPTs. One of the features of asthma are poorly understood circadian variations of bronchial obstruction. Methods. In 26 patients with asthma included in the research brnnchial provocation tests (BPT) with methacholine, propranolol, and distilled water were performed. From dose-response curves of BPTs PD2O (provocative dose) or PT2O (provocative time) for 20 per cent lowering of initial pulmonary function were calculated. 26 patients with asthma, 10 patients with chronic obstructive pulmonary disease (COPD) and 6 healthy subjects measured time series of PEF, which were analysed by F test and Fourier harmonic analysis. Results. Statistically significant correlation between PD2O ofBPT with methacholine and propranolol were found (r = O.679, p less th. O.001). They found significant negative correlation PD2O ofBPT with propranolol and circadian amplitudes of PEF (r= -0.39, p less th. 0.05) and positive correlation between parameter of F test F(7) and PT20 of bronchial provocation test with distilled water (r=0.44, p less th. 0. 05). By Fourier harmonic analysis they showed, that daily variations of PEF were very similar in patients with asthma and healthy subjects, but quite different in the COPD patients. Conclusions. For complete evaluation of individual NBHR BPTs with different classes of agonist should be done. Different shapes of diurnal variations of PEF in patients asthma and COPD patients could be used in differentiating between the two diseases. Results of the research suggest that the factors, that govern the level of NBHR, differ from the factors governing diurnal oscillations of PEF. | |
| Deskriptorji | ASTHMA LUNG DISEASES, OBSTRUCTIVE BRONCHIAL PROVOCATION TESTS METHACHOLINE CHLORIDE PROPRANOLOL WATER CIRCADIAN RHYTHM |