Avtor/Urednik		Brunskole, Mojca; Lanišnik-Rižner, Tea; Stojan, Jure
Naslov		Antimikotiki: sedanje in nove možnosti zdravljenja glivičnih okužb
Prevedeni naslov		Antimycotics: current and novel strategies for treatment of fungal infections
Tip		članek
Vir		Farm Vestn
Vol. in št.		Letnik 60, št. 6
Leto izdaje		2009
Obseg		str. 295-302
Abstrakt		Antifungal treatment is becoming more and more important as the incidence of invasive fungal infections is increasing. Currently, several antimycotics with diverse mechanisms of action are available, but their usage is often limited by their adverse effects and resistance. Novel strategies for the treatment of fungal infections are as follows: high-dose therapy, modulation of the pharmacokinetic properties of the drugs, combination therapy, immune system enhancement, and the development of new antifungal agents. Ideal antimycotics would have selectivity to fungal cells, low rates of resistance, broad antifungal activity, reduced toxicity and improved efficacy. The most promising antifungals are those targeting fungal cell wall components, protein biosynthesis and signaling pathways.
Deskriptorji		MYCOSES ANTIFUNGAL AGENTS DRUG RESISTANCE, MICROBIAL