Avtor/Urednik		Irman-Florjanc, T; Erjavec, F
Naslov		Kinetics of histamine and tele-methylhistamine elimination from rat plasma
Tip		članek
Vir		Agents Actions
Leto izdaje		1993
Obseg		str. C304-6
Jezik		eng
Abstrakt		Plasma levels of histamine (Hi) and tele-methylhistamine (MeHi) were measured by HPLC after intravenous bolus injection of Hi (45 micro g/kg) or MeHi (55 micro g/kg) in the rat. Increases in plasma Hi (from baseline 2.8 +- 0.4 to about 50 ng/ml at 2 min after the injection) were accompanied by a significant increase in MeHi levels (baseline 1.2 +- 0.3 ng/ml rising up to 11 ng/ml, 6 min after Hi application). After rapid intravenous injection, Hi and MeHi elimination from plasma could be fitted by a double exponential function with halflives in the alpha and beta phases of about 20 sec and 4 min (Hi) or 1 min and 43 min (MeHi). The results suggest that measurement of plasma MeHi, as an indirect marker of Hi release, has an advantage over measuring Hi itself.
Deskriptorji		HISTAMINE METHYLHISTAMINES RATS INJECTIONS, INTRAVENOUS TIME FACTORS CHROMATOGRAPHY, HIGH PRESSURE LIQUID