Avtor/Urednik		Jeverica, Samo; Tepeš, Bojan; Ihan, Alojz; Skvarč, Miha
Naslov		Primarna odpornost bakterije Helicobacter pylori
Prevedeni naslov		Primary resistance of Helicobacter pylori
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 79, št. 1
Leto izdaje		2010
Obseg		str. 25-30
Jezik		slo
Abstrakt		Background: Antimicrobial resistance, particularly against metronidazole and clarithromycin, is the leading cause for treatment failure of Helicobacter pylori infection. Eradication rates of primary therapy have fallen below 80% in the majority of states including Slovenia. Th e aim of the study was to assess primary resistance to key antibiotics used for eradication treatment. Patients and methods: Between 2007 and 2009 we isolated 97 strains of Helicobacter pylori from the treatment naive patients who have not previously underwent eradication treatment. Antimicrobial susceptibility testing was done using phenotypical methods. Etests and breakpoint agar dilution method for metronidazole. We analyzed resistance profi les of the isolated bacteria and presenteddistribution of different phenotypes of Helicobacter pylori. Results: Th e primary antimicrobial resistance for metronidazole and clarithromycin was 18.6% and 17.5%, respectively. Combined resistance for both metronidazole and clarithromycin was 4.1%. In our group of isolates we did not fi nd any resistance against amoxicillin and tetracycline. 3.1% of isolates were ciprofl oxacin resistant. Conclusions: Systematic surveillance of antimicrobial resistance of Helicobacter pylori is mandatory to adjust primary and subsequent eradication therapy. Performing antimicrobial susceptibility testing is a costly method and that is why it is important to fi nd resources to make it possible.
Deskriptorji		HELICOBACTER INFECTIONS HELICOBACTER PYLORI DRUG RESISTANCE, MICROBIAL METRONIDAZOLE CLARITHROMYCIN MICROBIAL SENSITIVITY TESTS