Avtor/Urednik		Coer, Andrej
Naslov		Histološka analiza obproteznih tkiv ob omajanih sklepnih protezah
Prevedeni naslov		Histological analysis of the periprosthetic tissue around failed joint arthroplasties
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 78, št. Suppl 2
Leto izdaje		2009
Obseg		str. II-79-84
Jezik		slo
Abstrakt		Joint replacement strategies have improved the quality of life for many patients; however, a broad view of the literature shows that over 10% of all implants still have to undergo operative revision. Loosening of orthopedic implants thus represents important medical and socioeconomic problem. There are two major clinical pictures of prosthesis loosening, i.e. 'aseptic' and 'septic' loosening. Morphologically it is possible to reliably detect an infection by quantifi cation of neutrophilic granulocytes in periprosthetic membrane tissue. Aseptic loosening may be reproducibly classifi ed by the detection of different types of wear particles (polyethylene, metal, ceramic and cement) as well as cellular response characteristics (macrophages, multinucleated giant cells, lymphocytes). Continuous research and a combination of histological and sophisticated molecular methods will provide a rational basis for the development of novel and effective ways of diagnosis, prevention and treatment of periprosthetic osteolysis.
Deskriptorji		JOINT PROSTHESIS PROSTHESIS FAILURE OSTEOLYSIS PROSTHESIS-RELATED INFECTIONS