Avtor/Urednik		Pečlin, Polona; Zdovc, Miro; Rozman, Janez
Naslov		Chronic stimulation of an autonomous nerve with platinum electrodes
Prevedeni naslov		Kronična stimulacija avtonomnega živca s platinastimi elektrodami
Tip		članek
Vir		Mater Tehnol
Vol. in št.		Letnik 44, št. 1
Leto izdaje		2010
Obseg		str. 25-9
Jezik		eng
Abstrakt		A spiral nerve cuff (cuff), including thirty-nine platinum electrodes, arranged in thirteen spiral sets of three electrodes (triplet), was installed on the mid-cervical left vagus nerve (vagus) of a Beagle dog. The relevant position of the particular compartment and the optimal stimulation intensities were identified by delivering stimulating pulses to each triplet. The largest mean change in the components of both the ECG and hemodynamic changes was elicited with a stimulating intensity ic = 2.5 mA applied to triplet9. Every two weeks the aforementioned compartment was stimulated for 20 min with rectangular, charge-balanced, biphasic, current pulses with the parameters: width 100 µs, intensity ic = 2.0 mA, frequency 20 Hz, and a time delay between the biphasic phases of 100 µs for the time period of 18 months. It was calculated that to induce neural damage a total injected charge of approximately 172.8 mA s per phase at a charge density of 0.1 µA s/mm2 was injected. At the end of the trial, the neural and encapsulation tissue subjacent to the central group of triplet 9 and the neural and encapsulation tissue subjacent to the silicone insulation were dissected free and analyzed. The extent of the pathology of the neural tissue caused by the presence of the cuff and/or by the electrochemical reactions and the surface of the stimulating cathode in triplet 9 were investigated using light microscopy. The results showed that the usage of a cuff was associated with a build up of connective tissue around the cuff as well as within the cuff. The results also showed that some tissue injury occurred beneath the stimulating cathode of triplet 9. Finally, the results showed an absence of any anomaly at the flat geometric surface of 2mm2 in stimulating the cathode of the triplet 9, which could be attributable to irreversible electrochemical reactions.
Deskriptorji		VAGUS NERVE ELECTRIC STIMULATION ELECTROCARDIOGRAPHY HEMODYNAMICS ELECTRODES, IMPLANTED DOGS PLATINUM