Avtor/Urednik		Berce, Vojko; Krajnc, Ivan; Potočnik, Uroš
Naslov		Biološka zdravila pri zdravljenju astme
Prevedeni naslov		Biologic drugs in asthma treatment
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 49, št. 1
Leto izdaje		2010
Obseg		str. 11-8
Jezik		slo
Abstrakt		Development of the new antiasthmatic drugs is directed ab ove all in the synthesis of the inhibitors of the proinflammatory cytokines and IgE antibodies. Several biologic drugs are tested for this purpose; most common of them are monoclonal antibodies or modified receptol-s. Experiments were also do ne with antiinflammatory cytokines, chemokine inhibitors, antilymphocytic antibodies, cell adhesion blockers and CpG oligonucleotides. The most promising drugs are those directed against interleukines IL-4, IL-S, IL-13, cytokine TNFa and IgE immunoglobulin. Humanized monoclonal antibody directed against immunoglobulin E binding site is the only biologic drug which is already us ed in the asthma treatment. Better understanding of the molecular mechanisms of asthma leads to the identification of the new therapeutic targets.
Deskriptorji		ASTHMA ANTIBODIES, MONOCLONAL IGE INTERLEUKIN-5 INTERLEUKIN-4 INTERLEUKIN-10 INTERLEUKIN-13 TUMOR NECROSIS FACTOR INFLAMMATION MEDIATORS