Avtor/Urednik		Hudler, Petra
Naslov		Molekularni mehanizmi tvorbe zasevkov
Prevedeni naslov		Molecular mechanisms of metastasis
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 49, št. 1
Leto izdaje		2010
Obseg		str. 63-76
Jezik		slo
Abstrakt		The spread of metastases from a primary site through blood or the lymphatic system, which results in the establishment of secondary tumors in distant locations, is the main cause of death in cancer patients. Recent molecular and clinical studies have expanded knowledge of mechanisms implicated in metastasis formation. The development of cells with metastatic potential requires a coordinated expression and function of genes in both tumor cells and cells from surrounding tissues. All of the events involved in the metastatic cascade (Le. angiogenesis, adhesion, migration, invasion, and growth) also play an important role in normal biological processes, such as reproduction, embryogenesis, wound healing, smooth muscle cell migration, lymphocyte trafficking and liver regeneration. The identification of molecules and signal pathways that contribute to metastasis is important for developing novel diagnostic and/or prognostic tests and for discovering novel therapeutic strategies to combat metastatic disease.
Deskriptorji		NEOPLASMS NEOPLASM METASTASIS SIGNAL TRANSDUCTION NEOPLASM INVASIVENESS LYMPHATIC METASTASIS TUMOR MARKERS, BIOLOGICAL