| Avtor/Urednik | Brajenović-Milić, Bojana; Tišljarić, Dubravka; Petrović, Oleg; Prodan, Mirko; Ristić, Smiljana; Marout, Jasminka; Herman, Radoslav; Kapović, Miljenko | |
| Naslov | The influence of fetal sex and mother's smoking and parity on AFP and free beta-HCG concentrations in amniotic fluid of unaffected second trimester pregnancies | |
| Tip | članek | |
| Vir | Gynaecol Perinatol | |
| Vol. in št. | Letnik 16, št. 1 | |
| Leto izdaje | 2007 | |
| Obseg | str. 14-8 | |
| Jezik | eng | |
| Abstrakt | Objective. The aim is to investigate the influence of mother's smoking and parity and fetal sex on AFP and free beta-hCG in amniotic fluid and to examine the correlation between maternal serum and amniotic fluid marker concentrations. Methods. The study was performed on 233 second-trimester amniotic fluid samples. In 75 women, blood sample was taken immediately before amniocentesis too. All pregnancies were singleton with normal fetal karyotype and outcome. Concentrations of AFP and free beta-hCG were determined by fluoroimmunoassay and converted to MoM, according to medians for unaffected pregnancies of the corresponding gestational age. Results. In smoking women, amniotic fluid free beta-hCG was significantly lower than in non-smoking ones (p=0.033), though AFP was not significantly different in regard to smoking habits (p=0.113). Significantly higher amniotic fluid free beta-hCG (p<0.001) and lower AFP (p=0.015) were found in female, in comparison to fetal male gender. No significant change according to parity, neither for free beta-hCG, nor for AFP was observed (p=0.094 and p=0.376, respectively). Significant correlation of AFP to free beta-hCG was found between serum and amniotic fluid samples (r=0.61, p<0.001 and r=0.35, p<0.002, respectively). Conclusions. Our results confirmed the influence of fetal sex on amniotic fluid AFP and free beta-hCG and negative influence of smoking on free beta-hCG as well as on maternal serum AFP and free beta-hCG concentrations. More data should be available to determine the impact of parity on examined amniotic fluid markers. | |
| Deskriptorji | PREGNANCY SMOKING AMNIOTIC FLUID FETUS SEX FACTORS ALPHA-FETOPROTEINS PREGNANCY TRIMESTER, SECOND CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN |