Avtor/Urednik		Zupan, Igor; Lipar, Luka
Naslov		Doseganje ciljne srčne frekvence, antiishemična učinkovitost in prenašanje zdravila ivabradin pri bolnikih s stabilno angino pektoris (raziskava OPTIMAL 60)
Prevedeni naslov		Target heart rate achievement, antiishemic drug efficacy and tolerability of ivabradin in patients with stable angina pectoris (OPTIMAL 60 study)
Tip		članek
Vir		Slov Kardiol
Vol. in št.		Letnik 7, št. 1
Leto izdaje		2010
Obseg		str. 36-40
Jezik		slo
Abstrakt		Heart rate reduction in patients with angina pectoris is basic method of treatment. Several different drugs are used, like beta-adrenergic receptor inhibitors, calcium channel blockers and selective If inhibitors. Beta-adrenergic receptor blockers are the drug of selection in patients with angina pectoris, but their use to achieve doses that were used in large dinical trials are in daily practice limited. Aims of the study OPTlMAL60 were to evaluate the target heart rate in patients with angina pectoris, to prove the efficacy and safety of treatment with ivabradin and to identify options for further and more effective adjunctive therapy in patients with angina pectoris. In the study , OPTIMAL60, reaching the target heart rate has been slightly lower than expected because the target heart rate reached only 35% of patients. This is probably due to a small number of patients that also received concomitant beta-adrenoceptor blockers because of possible side effects (asthma, diabetes, etc.). The second reason is probably in lower doses of ivabradin (5 mg/12 hours) and not higher ones (7.5 mg/12 hours). Interestingly, we nevertheless found statistically significant correlation between heart rate and lowering the number of attacks of angina pectoris. Even more important figure is probably a subjective response to treatment, because in our study, more than 90% of patients were satisfied with treatment. Ischemic heart disease is the leading cause 'of morbidity and mortality in the developed world and therefore the search for new treatment approaches are essential to control this key pandemic of the 21st century. We hope that the study OPTIMAL60 obtained relevant information that will help to improve treatment of patients with angina pectoris.
Deskriptorji		HEART RATE ANGINA PECTORIS MYOCARDIAL ISCHEMIA ANGIOTENSIN-CONVERTING ENZYME INHIBITORS