Avtor/Urednik		Stokin, Gorazd B; Goldstein, Lawrence SB
Naslov		Linking molecular motors to Alzheimer's disease
Tip		članek
Vir		J Physiol Paris
Vol. in št.		Letnik 99, št. 2-3
Leto izdaje		2006
Obseg		str. 193-200
Jezik		eng
Abstrakt		It is currently thought that Alzheimer's disease develops due to aberrant generation of amyloid-beta peptides. However, the mechanisms underlying the aberrant generation of amyloid-beta peptides remain unknown. An emerging concept suggests that impaired axonal transport may play a pivotal role in the aberrant generation of amyloid-beta peptides. Here we review and discuss advances in understanding AD with the primary focus on the possible role of molecular motors and axonal transport in its pathogenesis.
Deskriptorji		AMYLOID BETA-PROTEIN PRECURSOR ANIMALS AXONAL TRANSPORT AXONS MODELS, BIOLOGICAL