Avtor/Urednik		Goličnik, Marko
Naslov		Explicit reformulations of time-dependent solution for a Michaelis-Menten enzyme reaction model
Tip		članek
Vir		Anal Biochem
Vol. in št.		Letnik 406, št. 1
Leto izdaje		2010
Obseg		str. 94-6
Jezik		eng
Abstrakt		The exact closed-form solution to the Michaelis-Menten equation is expressed in terms of the Lambert W(x) function. However, the utility of this solution is limited because the W(x) function is not widely available in curve-fitting software. Based on various approximations to the W(x) function, different explicit equations expressed in terms of the elementary functions are proposed here as useful shortcuts to fit time depletion of substrate concentration directly to progress curves using commonly available nonlinear regression computer programs. The results are compared with those obtained by fitting other algebraic equations that have been proposed previously in the literature.
Deskriptorji		ENZYME ACTIVATION SOLUTIONS TIME FACTORS KINETICS SUBSTRATE CYCLING NONLINEAR DYNAMICS