Avtor/Urednik		Tomaževič, T; Ban-Frangež, H; Virant-Klun, I; Verdenik, I; Požlep, B; Vrtačnik-Bokal, E
Naslov		Septate, subseptate and arcuate uterus decrease pregnancy and live birth rates in IVF/ICSI
Tip		članek
Vir		Reprod Biomed
Vol. in št.		Letnik 21, št. 5
Leto izdaje		2010
Obseg		str. 700-5
Jezik		eng
Abstrakt		A retrospective matched-control study to evaluate the effect of uterine anomalies on pregnancy rates after 2481 embryo transfers in conventionally stimulated IVF/intracytoplasmic sperm injection (ICSI) cycles. The study group of 289 embryo transfers before and 538 embryo transfers following hysteroscopic resection of a uterine septum was compared with two consecutive embryo transfers in the control group. Groups were matched for age, body mass index, ovarian stimulation, embryo quality, IVF or ICSI and infertility aetiologies. Number of embryos transferred, embryo quality and absence of uterine anomalies significantly predicted the pregnancy rates in the study group: odds ratios (OR) 1.7, 2.6 and 2.5, respectively (P < 0.001). Pregnancy rates after embryo transfer before hysteroscopic metroplasty were significantly lower, both in women with subseptate and septate uterus and in women with arcuate uterus compared with controls. If two or three embryos with at least one best-quality embryo were transferred, the differences were 9.6% versus 43.6%, OR 7.3 (P < 0.001) and 20.9% versus 35.5%, OR 2.1 (P < 0.03), respectively. Differences in terms of live birth rates were even more evident: 1.9% versus 38.6%, OR 32 (P < 0.001) and 3.0% versus 30.4%, OR 14 (P < 0.001). After surgery, the differences disappeared.
Deskriptorji		INFERTILITY, FEMALE UTERUS HYSTEROSCOPY FERTILIZATION IN VITRO SPERMATOZOA EMBRYO TRANSFER PREGNANCY BIRTH RATE ODDS RATIO RETROSPECTIVE STUDIES