Avtor/Urednik		Pavčnik-Arnol, M; Bonač, B; Grošelj-Grenc, M; Derganc, M
Naslov		Changes in serum procalcitonin, interleukin 6, interleukin 8 and C-reactive protein in neonates after surgery
Tip		članek
Vir		Eur J Pediatr Surg
Vol. in št.		Letnik 20, št. 4
Leto izdaje		2010
Obseg		str. 262-6
Jezik		eng
Abstrakt		Introduction: Aim of this study was to determine the kinetics of procalcitonin (PCT), interleukin-6 (IL-6), interleukin-8 (IL-8) and C-reactive protein (CRP) serum concentrations after different types of neonatal surgery. Material and methods: We conducted a prospective, observational study in a level III multidisciplinary neonatal intensive care unit. We enrolled twenty-five (n=25) neonates undergoing major surgery (for gastroschisis, atresia of the small intestine, congenital diaphragmatic hernia, esophageal atresia, coarctation of the aorta, neurosurgical procedures). Serum PCT, IL-6, IL-8 and CRP were measured before surgery, immediately after surgery (POD 0) and on the first and second day after surgery (POD 1, 2). Results: Median preoperative serum concentrations were: PCT 1.3 microg/l, IL-6 985 fmol/l, IL-8 51 pg/ml, CRP 6 mg/l. PCT increased insignificantly after surgery with a peak median concentration on POD 1 (2.0 microg/l), but concentrations varied considerably between patients in the same category of surgery. IL-6 significantly increased on POD 0 (median 2 262 fmol/l), with a peak median concentration on POD 1 (3 410 fmol/l), and decreased thereafter. IL-8 increased significantly after surgery with a peak median concentration on POD 0 (125 pg/ml) and decreased thereafter. IL-8 response was very consistent after all types of surgery. CRP only began to increase on POD 1 (median 20 mg/l) with a peak median concentration on POD 2 (21 mg/l). Conclusion: The physiological increase in PCT after birth and the impact of underlying disease make the interpretation of postoperative values in the immediate postnatal period difficult. IL-6 is a very sensitive marker of neonatal surgical injury with considerable variation between different types of surgery. IL-8 response after neonatal surgery is similar after all types of surgery, very rapid and transient with relatively low concentrations. (Abs. trunc. at 2000 ch.)
Deskriptorji		POSTOPERATIVE PERIOD CALCITONIN INTERLEUKIN-6 C-REACTIVE PROTEIN INTERLEUKIN-8 GESTATIONAL AGE BIRTH WEIGHT INFANT, NEWBORN PROSPECTIVE STUDIES