Avtor/Urednik		Žiberna, L; Lunder, M; Tramer, F; Drevenšek, G; Passamonti, S
Naslov		The endothelial plasma membrane transporter bilitranslocate mediates rat aortic vasodilation induced by anthocyanins
Tip		članek
Vir		Nutr Metab Cardiovas
Vol. in št.		Letnik 23, št. 1
Leto izdaje		2013
Obseg		str. 68-74
Jezik		eng
Abstrakt		Background and aims: Anthocyanins, a sub-class of flavonoids, induce endothelium dependent vasorelaxation, by activating endothelial nitric oxide synthase and consequently increasing production of the vasorelaxant agent nitric oxide. It is not yet clear if anthocyanin-induced vasorelaxation starts with their interaction with plasma membrane receptors in the extracellular compartment, or with their membrane transport toward intracellular molecular targets. We therefore investigated the possible role of bilitranslocase (TC 2.A.65.1.1), an endothelial plasma membrane carrier that transports flavonoids, in the vasodilation activity induced by anthocyanins. Methods and results: Vascular reactivity was assessed in thoracic aortic rings obtained from male Wistar rats. Pre-treatment of aortic rings with anti-sequence bilitranslocase antibodies targeting the carrier, decreased vasodilation induced by cyanidin 3-glucoside and bilberry anthocyanins. Conclusion: Here we show for the first time that bilitranslocase mediates a critical step in vasodilation induced by anthocyanins. This offers new insights into the molecular mechanism involved in endothelium-dependent vasorelaxation by flavonoids, and the importance of their specific membrane carriers.
Deskriptorji		AORTA VASODILATION ENDOTHELIUM, VASCULAR BIOLOGICAL TRANSPORT, ACTIVE PLANT EXTRACTS ACETYLCHOLINE NITROPRUSSIDE IGG RATS, WISTAR