Avtor/Urednik     Sever, Matjaž; Kantarjian, Hagop; Pierce, Sherry; Jain, Nitin; Estrov, Zeev; Cortes, Jorge; Verstovsek, Srdan
Naslov     Cytogenetic abnormalities in essential thrombocythemia at presentation and transformation
Tip     članek
Vir     Int J Hematol
Vol. in št.     Letnik 90, št. 4
Leto izdaje     2009
Obseg     str. 522-5
Jezik     eng
Abstrakt     Cytogenetic abnormalities in patients with essential thrombocythemia (ET) are infrequent. Their role in survival of patients and disease transformation is not extensively studied. We describe cytogenetic abnormalities in 172 patients with ET at a single institution. At presentation nine (5.2%) patients had cytogenetic abnormality and three (1.7%) additional patients acquired them during follow-up. Survival of patients with cytogenetic changes at presentation did not differ when compared to the patients with normal karyotype. The more common were abnormalities of chromosome 9 (n = 4), 20 (n = 2), 5 (n = 2), and complex abnormalities (n = 2). Forty-one patients (23.8%) had additional cytogenetic tests performed for monitoring purposes during follow-up. Five patients (2.9%) with normal karyotype transformed to myelofibrosis (MF) without developing new cytogenetic changes at transformation. Two patients (1.2%) with normal karyotypes at presentation transformed to myelodysplastic syndrome and acute myeloid leukemia, respectively. Both acquired complex cytogenetic changes at the time of transformation. There is no rationale for repeating cytogenetic tests in ET patients on follow up, unless blood cell count changes suggest possible transformation.
Deskriptorji     ADULT
AGED
AGED, 80 AND OVER
BLOOD CELL COUNT
CELL TRANSFORMATION, NEOPLASTIC
CHROMOSOME ABERRATIONS
FOLLOW-UP STUDIES
MYELODYSPLASTIC SYNDROMES