Avtor/Urednik		Loew, O; Gabler, U; Mueller, A; Gabler, P; Schubert, H; Loew, H-C; Machnik, G
Naslov		Morphometry of connective tissue in rat livers
Tip		članek
Vir		Acta Stereol
Vol. in št.		Letnik 13, št. 1
Leto izdaje		1994
Obseg		str. 101-6
Jezik		eng
Abstrakt		Thioacetamide (TAA) induced fibrosis in the rat liver was used as a model for testing preparations for a prevention of cirrhosis. The homogeneity of collagen distribution between the lobes allows the morphometry of a single lobe as a measure for the total organ, but it is always better to estimate about 5 stage sections with equal distances, and these sections should be measured totally. A test period of 3 months results in a markable fibrosis, sufficient for testing antifibrotic preparations. Zinc ions in drinking water decrease the collagen percentages in comparison to untreated animals and reduce the TAA-induced fibrosis during simultaneously application over a 3 month period, since an addition only in the 3rd month diminishes this effect. No differences are seen after an interruption of the TAA-poisoning after 3 months and a feeding with zinc sulphate only in the 4th month, compared to clear drinking water.
Deskriptorji		LIVER THIOACETAMIDE LIVER CIRRHOSIS ANIMALS, LABORATORY RATS ZINC COMPOUNDS HISTOLOGICAL TECHNIQUES CONNECTIVE TISSUE