Avtor/Urednik		Gradišek, Primož; Osredkar, Joško; Kremžar, Boriana; Koršič, Marjan
Naslov		Biokemijski označevalci nezgodne možganske okvare
Prevedeni naslov		Biochemical markers of traumatic brain injury
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 80, št. 4
Leto izdaje		2011
Obseg		str. 293-301
Jezik		slo
Abstrakt		Background: Currently used clinical and radiological findings of particularly mild traumatic brain injury have limited diagnostic and prognostic value. Methods and results: We conducted a systematic review of selected primary clinical studies on biochemical markers of traumatic brain injury in the last 10 years, using an electronic search of the National Library of Medicine's database MEDLINE. The most explored and clinically relevant biochemical markers of acute brain injury are protein S100B, neuron-specific enolase and glial fibrillary acidic protein. In addition, novel markers such as spectrin breakdown product, c-tau and amiloid-b are presented. Based on clinical trials, the rationale for their use in the context of severity of traumatic brain injury is outlined. Conclusions: Measurement of biochemical markers of brain injury should be introduced in the clinical management of mild traumatic brain injury. The predictive value of current clinical and radiological findings can be markedly improved by the determination of biochemical markers in mild and severe traumatic brain injury.
Deskriptorji		BRAIN INJURIES BIOLOGICAL MARKERS PROTEIN S PHOSPHOPYRUVATE HYDRATASE GLIAL FIBRILLARY ACIDIC PROTEIN MYELIN BASIC PROTEINS GLASGOW COMA SCALE PROGNOSIS