Avtor/Urednik		Perko, Denis; Pretnar-Oblak, Janja; Šabovič, Mišo; Žvan, Bojana; Zaletel, Marjan
Naslov		Endothelium-dependent vasodilatation in migraine patients
Tip		članek
Vir		Cephalalgia
Vol. in št.		Letnik 31, št. 6
Leto izdaje		2011
Obseg		str. 654-60
Jezik		eng
Abstrakt		Background: Endothelial dysfunction could be involved in the pathophysiology of migraine. The results obtained from a few studies on endothelial dysfunction in migraine are controversial. We investigated brachial flow-mediated dilatation (FMD), which reflects systemic endothelial dysfunction, in migraine patients without comorbidities. By employing strict inclusion criteria we avoided the possible changes to FMD from confounding factors. Methods. Forty migraine patients without comorbidities (20 with and 20 without aura) and 20 healthy subjects were included. FMD of brachial arteries and carotid intima-media thickness were measured by using standard procedures. Results. We did not find any difference in FMD between migraine patients and healthy subjects (p=.96). Also, no differences were found among healthy subjects, migraine patients with aura and without aura (p=.99). Conclusion. Our study showed that systemic endothelial function is not impaired in migraine patients without comorbidities, neither in those with or without aura. Considering these findings, the investigation of cerebral endothelial function would be useful in a further investigation of the role of endothelial (dys)function in migraine pathophysiology.
Deskriptorji		MIGRAINE ENDOTHELIUM, VASCULAR VASODILATION BRACHIAL ARTERY CAROTID ARTERIES ADULT TUNICA INTIMA TUNICA MEDIA BLOOD FLOW VELOCITY ULTRASONOGRAPHY, DOPPLER, DUPLEX LINEAR MODELS