Avtor/Urednik		Bavec, Aljoša
Naslov		Structure, function and regulation of group IV phospholipase A2 family
Tip		članek
Vir		Acta Chim Slov
Vol. in št.		Letnik 58, št. 2
Leto izdaje		2011
Obseg		str. 195-202
Jezik		eng
Abstrakt		The Group IV phospholipase A2 family is consisted of six intracellular enzymes. They catalyze hydrolysis of the sn-2 ester bond of glycerophospholipids, releasing fatty acid metabolites and lysophospholipids. Agonist-induced release of arachidonic acid for the production of eicosanoids by PLA2IValpha enzyme is important in regulating normal and pathological processes in a variety of target tissues. Here, we compare PLA2IValpha, and its paralogs beta, gamma, delta, epsilon and zeta in term of of their structure, function and regulation.
Izvleček		Skupina IV fosfolipaz A2 trenutno obsega šest encimov. Encimi katalizirajo hidrolizo sn-2 estrske vezi glicerofosfolpidov, pri čemer nastane maščobna kislina in lizofosfolipid. Največkrat je produkt hidrolize arahidonska kislina, ki se pretvarja v aktivne eikozanoide, ki imajo pomembno vlogo pri regulaciji celičnih procesov v različnih tarčnih tkivih. V tem prispevku si bomo pogledali strukturo, funkcijo in regulacijo encima PLA2IValpha in jo primerjali z ostalimi predstavniki skupine IV fosfolipaz A2, in sicer z beta, gama, delta, epsilon in zeta.
Deskriptorji		PHOSPHOLIPASES A CYTOSOL PHOSPHOLIPIDS LYSOPHOSPHOLIPIDS ARACHIDONIC ACID EICOSANOIDS