Avtor/Urednik		Uršič, Tina
Naslov		Pogostnost in klinični pomen okužbe s človeškim bokavirusom pri otrocih v Sloveniji
Prevedeni naslov		Frequency and clinical assessment of human bocavirus infection in Slovenian children
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2011
Obseg		str. 120
Jezik		slo
Abstrakt		Recent studies suggests that newly discovered human bocavirus (HBoV) is etiologicaly linked to respiratory tract infections in children. HBoV was detected in children with upper and lower respiratory tract infections, in children with acute wheezing, children with asthma exacerbation, in immunocompromised patients and asymptomatic children and adults. It is suggested that HBoV is endemic virus, with high frequency of infection in children under three years of age. As previously reported, HBoV was frequently found with other viruses, consequently the etiological role of HBoV as a cause of respiratory tract infection is still under investigation. Although the evidence for pathogenicity of HBoV is increasing, more studies are needed to determine severity of HBoV-associated diseases and clinical outcomes. However, researchers suggests that high viral loads associates with acute HBoV infection and low viral loads with previous infection or even persistence of HBoV DNA. Consequently the aim of many recent studies is serological confirmation of primary (acute) HBoV infection. In this retrospective study the frequency and clinical importance of HBoV among hospitalized children with acute respiratory tract infection (ARTI) were investigated. According to available literature the present study is one of the largest studies on HBoV clinical importance. During the study period, 891 respiratory samples of 760 different pediatric patients, were collected. Each of 891 samples represented different hospitalization event. The demographic, clinical and laboratory parameters were retrospectively collected from hospital charts. Respiratory syncytial virus (RSV), adenoviruses (AdV), parainfluenza viruses 1, 2 and 3 (PIV1-3), and influenzae viruses A and B (INF A/B) were detected using direct immunofluorescence assay (DFA). (Abstract truncated at 2000 characters)
Deskriptorji		RESPIRATORY TRACT INFECTIONS CHILD, HOSPITALIZED VIRUS DISEASES VIRAL LOAD FLUORESCENT ANTIBODY TECHNIQUE, DIRECT CHILD POLYMERASE CHAIN REACTION