Avtor/Urednik		Meznarič-Petruša, M; Eržen, I; Zidar, J
Naslov		Dystrophin-significance for diagnostics of neuromuscular diseases
Tip		članek
Vir		Basic and applied myology
Vol. in št.		Letnik 2, št. 4
Leto izdaje		1992
Obseg		str. 255-60
Jezik		eng
Abstrakt		Immunoperoxidase reaction for dystrophin was performed using monoclonal antibodies to central rod domain and C-terminus. It was confirmed that the diagnosis of Duchenne muscular dystrophy can be already established immunohistochemically, based on the absence of immunoreactivity with antibodies to C-terminus. In eight male patients where Becker muscular dystrophy (BMD) was considered in the differential diagnosis, immunolabelling with antibodies to rod domain was indistinguishable from normal. Only in one patient, where discontinuous patttern of immunolabelling of dystriphin was observed, the diagnosis of BMD was established immunohistochemically. Our results show, that immunohistochemical analysis alone cannot always diagnose BMD and are in agreement with some observations from the literature.
Deskriptorji		DYSTROPHIN IMMUNOHISTOCHEMISTRY MUSCULAR DYSTROPHY DIAGNOSIS, DIFFERENTIAL DYSTROPHIN