Avtor/Urednik		Jurčić, V; Ferluga, D; Vizjak, A; Hojnik, M; Božič, B; Rozman, B; Jakša, I
Naslov		Endotelna celica in antiendotelna protitelesa
Prevedeni naslov		Endothelial cell and anti-endothelial cell antibodies
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 63, št. 11
Leto izdaje		1994
Obseg		str. 671-5
Jezik		slo
Abstrakt		Background. Endothelium is morphologically heterogenous-continuous, discontinuous and fenestrated. Endothelial cells play an active role in the basement membrane turn over, regulation of vascular tonus, blood flow and coagulation, in the metabolism of lipoproteins and angiogenesis. They are the target of various exogenous and endogenous noxious agents. Endothelial cells play an important role in immune and nonimmune pathologic processes. Of particular importance in these processes are adhesion molecules on the surface of the endothelial cells. Recent investigations of immune mechanisms involved in endothelial cell damage have indicated the significance of anti-endothelial cell antibodies, wich were demonstrated in the sera in different diseases, especially systemic connective tissue diseases. In vitro studies and animal models have shown that they might damage the endothelial cell. However, the target antigens are still undefined. Only occasional studies stress the relationship between anti-endothelial cell antibodies and disease activity. Conclusions. The pathogenic role of these antibodies is poorly established and their diagnostic significance remains to be determined. It seems possible that anti-endothelial cell antibodies assay will not be a specific diagnostic test but an indicator of vascular involvement in various diseases.
Deskriptorji		ENDOTHELIUM ANTIBODIES ENDOTHELIUM, VASCULAR ANTIBODIES, ANTICARDIOLIPIN