Avtor/Urednik		Pennanen, Luis; Welzl, Hans; D'Adamo, Patrizia; Nitsch, Roger M; Gotz, Juergen
Naslov		Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice
Tip		članek
Vir		Neurobiol Dis
Vol. in št.		Letnik 15, št. 3
Leto izdaje		2004
Obseg		str. 500-9
Jezik		eng
Abstrakt		Neurofibrillary tangles, insoluble protein deposits composed of filamentous tau aggregates, are neuropathological hallmarks of Alzheimer's disease and familial frontotemporal dementia (FTDP-17). Transgenic mice expressing the FTDP-17 mutation P301L of tau recapitulate key features of the human pathology, that is, tau proteins aggregate and neurofibrillary tangles begin to appear in the amygdala at 6 months of age. To detect early signs of tau aggregate-associated changes, we investigated behavioral alterations and cognitive deficits in such mice using an amygdala-specific test battery for anxiety-related and cognitive behavior. P301L mice had anxiety levels not different from wild-types, but their exploratory behavior was significantly increased. Acquisition of a fear response to tone and context as well as taste aversion was comparable to wild-types. However, extinction of a conditioned taste aversion was significantly accelerated. We conclude that already aggregation of tau proteins not yet accompanied by massive formation of neurofibrillary tangles causes selective behavioral deficits.
Deskriptorji		ANIMALS ANXIETY BEHAVIOR, ANIMAL BRAIN CONDITIONING, CLASSICAL DISEASE MODELS, ANIMAL IMMUNOHISTOCHEMISTRY MICE MICE, TRANSGENIC MICROTUBULE-ASSOCIATED PROTEINS NEUROFIBRILLARY TANGLES TASTE TAU PROTEINS