Avtor/Urednik		Springer, Jochen; Lainščak, Mitja; Salobir, Barbara; Lang, Irene M
Naslov		Treatment of pulmonary hypertension: bench to bedside
Tip		članek
Vir		Respir Med
Vol. in št.		Letnik 105, št. Suppl 1
Leto izdaje		2011
Obseg		str. S7-11
Jezik		eng
Abstrakt		Pulmonary arterial hypertension is an orphan disease and a model for drug developments over recent years. Expert centers have focused basic science on the pulmonary vasculature and the right ventricle, followed by a direct transfer of innovative concepts to clinical research. Successful examples for translational experimentation are the endothelin receptor antagonists, prostacyclin receptor agonists, and the activators of soluble guanylate cyclase. On the other hand, there have been failures such as vasoactive intestinal peptide, statins, and escitalopram. Several new drugs and gene therapy are under investigation, thus significant advances are anticipated.
Deskriptorji		HYPERTENSION, PULMONARY VASODILATOR AGENTS EPOPROSTENOL ENDOTHELINS PHOSPHODIESTERASE INHIBITORS ESTRADIOL ANGIOTENSIN-CONVERTING ENZYME INHIBITORS