Avtor/Urednik		Rijavec, Matija; Volarevič, Siniša; Osolnik, Katarina; Košnik, Mitja; Korošec, Peter
Naslov		Natural killer T cells in pulmonary disorders
Tip		članek
Vir		Respir Med
Vol. in št.		Letnik 105, št. Suppl 1
Leto izdaje		2011
Obseg		str. S20-5
Jezik		eng
Abstrakt		Natural killer T (NKT) cells, a unique subgroup of lymphocytes with features of both T and natural killer (NK) cells, represent a bridge between innate and adaptive immunity. They have the ability to either promote or suppress immune responses. With these immunoregulatory functions, NKT cells have emerged as an important subset of lymphocytes with a protective role in some disorders, such as infections, cancer, and possibly sarcoidosis, and a pathogenic role in others, such as asthma, chronic obstructive pulmonary disease and hypersensitivity pneumonitis. Immunotherapeutic interventions to modulate the immune response by targeting iNKT cell functions has become a challenging field and has shown promising results for the development of new therapies.
Deskriptorji		ASTHMA LUNG DISEASES, OBSTRUCTIVE SARCOIDOSIS ALVEOLITIS, EXTRINSIC ALLERGIC KILLER CELLS, NATURAL TUBERCULOSIS