Avtor/Urednik     Farinazzo-Vitral, Geraldo-Sergio; Rezende-Barbosa-Raposo, Nadia
Naslov     Polydimethylsiloxane: a new contrast material for localization of occult breast lesions
Prevedeni naslov     Polidimetilsiloksan: novi kontrastni material za lokalizacijo okultnih lezij v dojki
Tip     članek
Vir     Radiol Oncol
Vol. in št.     Letnik 45, št. 3
Leto izdaje     2011
Obseg     str. 166-73
ISSN     1318-2099
Jezik     eng
Abstrakt     Background. The radioguided localization of occult breast lesions (ROLL) technique often utilizes iodinated radiographic contrast to assure that the local injection of 99mTc-MAA corresponds to the location of the lesion under investigation. However, for this application, this contrast has several shortcomings. The objective of this study was to evaluate the safety, effectiveness and technical feasibility of the use of polydimethylsiloxane (PDMS) as radiological contrast and tissue marker in ROLL. Materials and methods. The safety assessment was performed by the acute toxicity study in Wistar rats (n = 50). The radiological analysis of breast tissue (n = 32) from patients undergoing reductive mammoplasty was used to verify the effectiveness of PDMS as contrast media. The technical feasibility was evaluated through the scintigraphic and histologic analysis. Results. We found no toxic effects of PDMS for this use during the observational period. It has been demonstrated in human breast tissue that the average diameter of the tissue marked by PDMS was lower than when marked by the contrast medium (p <0.001). PDMS did not interfere with the scintigraphic uptake (p = 0.528) and there was no injury in histological processing of samples. Conclusions. This study demonstrated not only the superiority of PDMS as radiological contrast in relation to the iodinated contrast, but also the technical feasibility for the same applicability in the ROLL. Key words: breast cancer; surgery; radiological contrast; ROLL technique
Deskriptorji     BREAST NEOPLASMS
DIMETHYLPOLYSILOXANES
CONTRAST MEDIA
MAMMOGRAPHY
DISEASE MODELS, ANIMAL
RATS, WISTAR