Avtor/Urednik		Oblak, Irena; Anderluh, Franc; Velenik, Vaneja; Mozina, Barbara; Ocvirk, Janja; Ciric, Eva; Hrovatic-Podvrsnik, Natasa
Naslov		Differences in plasma TIMP-1 levels between healthy people and patients with rectal cancer stage II or III
Prevedeni naslov		Razlike v vrednostih TIMP-1 v plazmi med zdravimi darovalci krvi in bolniki z rakom danke stadija II ali III
Tip		članek
Vir		Radiol Oncol
Vol. in št.		Letnik 45, št. 3
Leto izdaje		2011
Obseg		str. 209-212
Jezik		eng
Abstrakt		Background. The purpose of the study was to analyse whether the levels of the tissue inhibitor of matrix metalloproteinases- 1 (TIMP-1) are higher in patients with rectal cancer as compared with healthy blood donors. Patients and methods. Two hundred and seventeen patients (147 male, 70 female) with histologically confirmed non-metastatic rectal cancer (clinical stage II-III) and 45 healthy blood donors (15 male, 30 female) were included in analysis. Patient's mean age was 66 years (range: 34-87 years) and healthy blood donor's mean age was 35 years (range: 18-64 years). Plasma TIMP-1 concentrations were measured with an enzyme-linked immunosorbent assay (ELISA) using commercially available TIMP-1 ELISA kit. Mann-Whitney-test for independent groups was used to assess the differences of plasma TIMP-1 levels and clinicopathological parameters. Two-sided tests were used and the differences at P<0.05 were considered as statistically significant. Results. Median patients TIMP-1 level was 180 ng/mL (range: 22-538 ng/mL); the mean ('bSD) level was 193.7 (79.5) ng/mL. The median healthy blood donors TIMP-1 level was 112 ng/mL (range: 48-211 ng/mL); the mean (?bSD) level was 115 (35.7) ng/mL. TIMP-1 levels in patients with rectal cancer were statistically significantly higher than TIMP-1 levels in healthy blood donors (P<0.0001). Significant differences in TIMP-1 levels were not found comparing gender (P=0.43), but in both groups TIMP-1 levels were increased with higher age (P=0.007). Conclusions. Patients with rectal cancer had statistically significantly higher mean and median TIMP-1 level than healthy blood donors which is in accordance with the results published in other publications. These findings suggest possibility that plasma TIMP-1 levels could be used as new biological markers for early cancer detection. Key words: TIMP-1; rectal cancer; healthy blood donors Introduction Tumour aggressiveness and metastatic potential, resulting in a poor prognosis, have been sho
Deskriptorji		RECTAL NEOPLASMS NEOPLASM STAGING METALLOPROTEINASES PROTEASE INHIBITORS BLOOD DONORS