Avtor/Urednik		Tezcan, Yilmaz; Koc, Mehmet
Naslov		3-D conformal radiotherapy with concomitant and adjuvant temozolomide for patients with glioblastoma multiforme and evaluation of prognostic factors
Prevedeni naslov		3-D konformno obsevanje s hkratnim in dodatnim zdravljenjem s temozolomidom pri bolnikih z multiformnim glioblastomom in določitev napovednih dejavnikov
Tip		članek
Vir		Radiol Oncol
Vol. in št.		Letnik 45, št. 3
Leto izdaje		2011
Obseg		str. 213-9
Jezik		eng
Abstrakt		Background. The aim of the retrospective study was to evaluate the outcome and prognostic factors of newly diagnosed glioblastoma patients who received 3-D conformal radiotherapy (RT) combined with concomitant and/or adjuvant temozalamide (TMZ) postoperatively. Patients and methods. Fifty patients with glioblastoma multiforme were treated with 3-D conformal RT combined with concomitant and/or adjuvant TMZ postoperatively. Median age was 57 years (range, 12-79) and median Karnofsky performance status (KPS) was 70 (range, 40-100). A multivariate Cox regression model was used to test the effect of age, sex, KPS, extent of surgery, tumour dimension (<5cm vs. ? 5cm), full dose RT (? 60 Gy vs. <60 Gy), concurrent TMZ and adjuvant TMZ treatment (adjuvant therapy plus 6 cycles of TMZ group versus <6 cycles of TMZ group) on the overall survival. Results. The median follow up time was 10 months (range 3-42). One- and 2-year overall survival rates were 46% and 20%, respectively. The prognostic factors important for the overall survival were a full dose RT (? 60 Gy) (p=0.005) and the application of adjuvant TMZ for 6 cycles (p=0.009). Conclusions. The results of our study confirm the efficiency of RT plus concomitant and adjuvant TMZ, with an acceptable toxicity in patients. We suggest that at least 6 cycles of adjuvant TMZ should be administered to obtain a benefit from the adjuvant treatment. Key words: glioblastoma multiforme; conformal radiotherapy; temozolomide; prognostic factors
Deskriptorji		GLIOBLASTOMA RADIOTHERAPY, COMPUTER-ASSISTED RADIOTHERAPY DOSAGE RADIOTHERAPY, ADJUVANT SURVIVAL ANALYSIS MULTIVARIATE ANALYSIS RETROSPECTIVE STUDIES