Avtor/Urednik		Mathias, Christopher J; Low, David A; Iodice, Valeria; Owens, Andrew P; Kirbiš, Mojca; Grahame, Rodney
Naslov		Postural tachycardia syndrome-current experience and concepts
Tip		članek
Vir		Nat Rev Neurol
Vol. in št.		Letnik 8, št. 1
Leto izdaje		2011
Obseg		str. 22-34
Jezik		eng
Abstrakt		Postural tachycardia syndrome (PoTS) is a poorly understood but important cause of orthostatic intolerance resulting from cardiovascular autonomic dysfunction. PoTS is distinct from the syndromes of autonomic failure usually associated with orthostatic hypotension, such as pure autonomic failure and multiple system atrophy. Individuals affected by PoTS are mainly young (aged between 15 years and 40 years) and predominantly female. The symptoms-palpitations, dizziness and occasionally syncope-mainly occur when the patient is standing upright, and are often relieved by sitting or lying flat. Common stimuli in daily life, such as modest exertion, food ingestion and heat, are now recognized to be capable of exacerbating the symptoms. Onset of the syndrome can be linked to infection, trauma, surgery or stress. PoTS can be associated with various other disorders; in particular, joint hypermobility syndrome (also known as Ehlers-Danlos syndrome hypermobility type, formerly termed Ehlers-Danlos syndrome type III). This Review describes the characteristics and neuroepidemiology of PoTS, and outlines possible pathophysiological mechanisms of this syndrome, as well as current and investigational treatments.
Deskriptorji		TACHYCARDIA POSTURE HYPOTENSION, ORTHOSTATIC DIZZINESS SYNCOPE PANIC ANXIETY