Avtor/Urednik		Flašker, Ajda; Rituper, Boštjan; Zorec, Robert
Naslov		Vpogled v uravnavano eksocitozo: vloga lipidov
Prevedeni naslov		Insight into regulated exocytosis: role of lipids
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 50, št. 4
Leto izdaje		2011
Obseg		str. 403-17
Jezik		slo
Abstrakt		Exocytosis, part of which is the merger of the vesicle and the plasma membrane, is characteristic for eukaryotic cells, which engage this process in a myriad of cell functions. For a long time it was believed that exocytosis was predominantly regulated by proteins, a view referred to as 'proteocentric'. Only recently it was shown that many oflipids, previously considered as passive cell membrane components, also play vital roles in regulation of exocytosis. Among others, such lipids are phosphatidylinositol-4,5-biphosphate, diacylglycerol, polyunsaturated fatty acids, sphingosine and cholesterol. Much like proteins, lipids act at various points in the process and influence exocytosis in various ways. The goal of this article is to highlight the role of lipids in exocytosis.
Deskriptorji		EXOCYTOSIS MEMBRANE FUSION MEMBRANE LIPIDS PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE DIGLYCERIDES FATTY ACIDS, UNSATURATED CHOLESTEROL SPHINGOSINE MEMBRANE PROTEINS BOTULISM OCULOCEREBRORENAL SYNDROME NIEMANN-PICK DISEASE