Avtor/Urednik     Kusters, DM; de Beaufort, C; Widhalm, K; Guardamagna, O; Bratina, N; Ose, L; Wiegman, A
Naslov     Paediatric screening for hypercholesterolaemia in Europe
Tip     članek
Vir     Arch Dis Child
Vol. in št.     Letnik 97, št. 3
Leto izdaje     2012
Obseg     str. 272-6
Jezik     eng
Abstrakt     Different screening strategies are currently recommended to identify children with (familial) hypercholesterolaemia in order to initiate early lipid management. However, these strategies are characterised to date by low adherence by the medical community and limited compliance by parents and children. In a literature review, the authors assess which children should undergo screening and which children are in effect identified through the currently recommended strategies. Furthermore, the authors discuss the different screening tools and strategies currently used in Europe and what is known about the negative aspects of screening. The authors conclude that currently recommended selective screening strategies, which are mainly based on family history, lack precision and that a large percentage of affected children who are at increased risk of future coronary artery disease are not being identified. The authors propose universal screening of children between 1 and 9 years of age, a strategy likely to be most effective in terms of sensitivity and specificity for the identification of children with familial hypercholesterolaemia. However, this concept has yet to be proven in clinical practice.
Deskriptorji     HYPERCHOLESTEROLEMIA, FAMILIAL
MASS SCREENING
MULTICENTER STUDIES
EUROPE