Avtor/Urednik		Lekič, Mirko; Kovač, Viljem; Triller, Nadja; Knez, Lea; Sadikov, Aleksander; Čufer, Tanja
Naslov		Outcome of small cell lung cancner (SCLC) patients with brain metastases in a routine clinical setting
Prevedeni naslov		Analiza bolnikov z drobnoceličnim rakom pljuč in možganskimi zasevki v klinični praksi
Tip		članek
Vir		Radiol Oncol
Vol. in št.		Letnik 46, št. 1
Leto izdaje		2012
Obseg		str. 54-9
Jezik		eng
Abstrakt		Background. Small cell lung cancer (SCLC) represents approximately 13 to 18% of all lung cancers. It is the most aggressive among lung cancers, mostly presented at an advanced stage, with median survival rates of 10 to12 months in patients treated with standard chemotherapy and radiotherapy. In approximately 15-20% of patients brain metastases are present already at the time of primary diagnosis; however, it is unclear how much it influences the outcome of disease according the other metastatic localisation. The objective of this analysis was to evaluate the median survival of SCLC patients treated by specific therapy (chemotherapy and/or radiotherapy) with regard to the presence or absence of brain metastases at the time of diagnosis. Patients and methods. All SCLC patients have been treated in a routine clinical practice and followed up at theUniversity Clinic Golnik in Slovenia. In the retrospective study the medical files from 2002 to 2007 were review. All patients with cytological or histological confirmed disease and eligible for specific oncological treatment were included in the study. They have been treated according to the guidelines valid at the time. Chemotherapy and regular followed-up were carried out at the University Clinic Golnik and radiotherapy at the Institute of Oncology Ljubljana. Results. We found 251 patients eligible for the study. The median age of them was 65 years, majority were male (67%), smokers or ex-smokers (98%), with performance status 0 to 1 (83%). At the time of diagnosis no metastases were found in 64 patients (25.5%) and metastases outside the brain were presented in 153 (61.0%). Brain metastases, confirmedby a CT scan, were present in 34 patients (13.5%), most of them had also metastases at other localisations. (Abstract truncated at 2000 characters)
Deskriptorji		LUNG NEOPLASMS CARCINOMA, SMALL CELL NEOPLASM METASTASIS BRAIN NEOPLASMS TREATMENT OUTCOME FOLLOW-UP STUDIES