Avtor/Urednik | Čolić, M; Vučević, D; Stojanovič, N; Lukić, T; Gašić, S; Popović, Lj; Pavlović, D; Pejnović, N; Dujić, A | |
Naslov | Similarities and differences in phenotypical and functional characteristics of cloned thymic epithelial cell lines | |
Prevedeni naslov | Sličnosti i razlike fenotipskih i funkcionalnih osobina kloniranih epitelnih ćelijskih linija timusa | |
Tip | članek | |
Vir | Vojnosanit Pregl | |
Vol. in št. | Letnik 51, št. 4 Suppl | |
Leto izdaje | 1994 | |
Obseg | str. 9-12 | |
Jezik | eng | |
Abstrakt | Two rat thymic epithelial ceH (TEC) lines (R-TNC.l and TE-R 2.5) have been established. Mul~marker phenotypical analysis showed that they are of cortical and medullarx o1igin, respectively. These lines possessed certain common functicnal activities, such as binding of thymocytes, stimulation of non-adherent thymocyte (NAT) proliferation in a ConA assay and production of IL-l, IL-6 as well as macrophage proliferation factor(s). Some differences were also observed. The R-TNC.l line had nursing activity manifested as thymocyte emperiopolesis. In addition, it stimulated the proliferation both of thymocytes and thymic T-cell hybridomas of immature phenotype. In contrast, the TE-R 2.5 line inhibited the growth of these hybridomas and the inhibition was shown to be dependent on dir.ect cell-cell contacts. |