Avtor/Urednik		Skvarča, A; Tomažič, M; Krhin, B; Blagus, R; Janež, Andrej
Naslov		Adipocytokines and insulin resistance across various degrees of glucose tolerance in pregnancy
Tip		članek
Vir		J Int Med Res
Vol. in št.		Letnik 40, št. 2
Leto izdaje		2012
Obseg		str. 583-9
Jezik		eng
Abstrakt		Objective: Gestational diabetes meIlitus is characterized by progressive insulin resistance. Adipocytokines are thought to be associated with insulin resistance. This cross-sectional study evaluated the associations between serum concentrations of several adipocytokines and insulin resistance at different stages of glucose tolerance in pregnancy, using the homeostasis model assessment of insulin resistance (HaMA-IR) as a reference. Methods: According to oral glucose tolerance test results, 74 pregnant women were divided into three groups: normal glucose tolerance (n = 25); intermediate glucose tolerance (n = 19); gestational diabetes meIlitus (n = 30). Adiponectin, leptin, resistin, visfatin and retinolbinding protein 4 (RBP4) concentrations were measured using enzyme-Unked immunosorbent assays. Results: Groups were comparable regarding age, week of gestation and body mass index before gestation. There were statistically significant between-grDup differences in HOMA-IR, but no significant differences regarding serum adipocytokine concentrations. Conclusions: Adiponectin, leptin, resistin, visfatin and RBP4 we re not associated with the degree of glucose tolerance in pregnancy. Concentrations of these adipocytokines are not sufficiently sensitive to replace HOMAIR in pregnancy.
Deskriptorji		DIABETES, GESTATIONAL GLUCOSE TOLERANCE TEST INSULIN RESISTANCE ADIPOCYTES CYTOKINES ENZYME-LINKED IMMUNOSORBENT ASSAY INSULIN BODY MASS INDEX CROSS-SECTIONAL STUDIES