Avtor/Urednik		Bren, AF; Kaplan-Pavlovčič, S; Koselj, M; Kveder, R; Ferluga, D; Vizjak, A; Kandus, A; Ponikvar, R; Avšič-Županc, T; Poljak, M
Naslov		Hemorrhagic fever with renal syndrome (HFRS) presenting with acute renal failure (ARF) - 10 years survey
Tip		članek
Vir		In: Papadimitriou M, Alexopoulos E, eds. 3rd international symposium on acute renal failure: proceedings. Halkidiki: University studio press,
Leto izdaje		1993
Obseg		str. 457-61
Jezik		eng
Abstrakt		The causative agents of the haemorrhagic fever with renal syndrome (HFRS) are viruses belonging to the Hantavirus genus. As morphologic and biochemical studies have shown, it is possible to include the Hantaan and alike viruses in the Bunyaviridae family. Micromammals, especially sylvan and field mice, vales and rats, are the natural reservoir of Hantaviruses. Therefore they are important in epizootic process whose man isn't bu tan accindental member. Hantaviruses cause a chronic, asymptomatic infection in their hosts. The knowledge of the biology of micromammals is a key for understanding the epidemiology of infection in man. It is interesting that the antigenic, genetic, epidemiologic and ecologic properties of different Hantavirus strains are similar. Still isn't clear how many antigenic varieties influence directly on the pathogenity of Hantaviruses. By epidemiologic investigation HFRS in Slovenia we found out the natural focuses of disease and proved that about 12 per cent of the different species of micromammals are infected by Hantaviruses. We found out that in Slovenia at least two Hantaviruses serotypes are circulating and conseyuently that there are different clinical courses, of disease in our patients (serious and mild form) and different serologic responses. Till now we succeed to isolate three Hantavirus strains from different species of rodents (A. flavisollis, M. Musculus, A. agrarius) and one from the urine and the brain od a patient dead of HFRS. By serologic and molecular-biological methods we proved that most of isolated viruses belong to the Hantaan type, and that the isolatum from A. flavicollis (named Dobrava) is a new type of the Hantavirus genus. In the past 10 years, 70 patients (pts) with HFRS were registered in Slovenia (2 M inhabitants). Twentyseven pts were admitted to our center due to ARF. Infection with Hantaan (H) virus was established in 17 and with Puumala (P) in 10 pts.(trunc.)
Deskriptorji		HEMORRHAGIC FEVER, EPIDEMIC KIDNEY FAILURE, ACUTE SLOVENIA HANTAAN VIRUS KIDNEY FAILURE, ACUTE